Trigeminal pain pathway: peripheral and central activation as experimental models of migraine.
نویسنده
چکیده
The trigeminal pain pathway, as related to migraine, is represented by three main sites: i) the trigeminal nerve and ganglion providing unmyelinated C fibers that innervate the vessels (the trigeminovascular system) and the central projections to the brainstem; ii) the trigeminal nucleus caudalis (TNC) in the brainstem; and iii) the brain as the site of pain consciousness. Each of these sites has been suggested to be the essential one in migraine pathophysiology. This review outlines the experimental findings that support the hypothesis that both peripheral and central components are involved in migraine pathophysiology and drug activity.
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عنوان ژورنال:
- Functional neurology
دوره 16 4 Suppl شماره
صفحات -
تاریخ انتشار 2001